NEWS:

LATEST STUDIES:

Selected Articles



Abbasi K, Godlee F. Next steps in trial registration. BMJ 2005;330:1222-3.

Chan AW, Altman DG. Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors. BMJ 2005;330(7494):753.

Choonara I, Jacqz-Aigrain E. Improving drug therapy for children in Europe. Paediatr Perinat Dr Ther 2005;6:147-48

Chui J, Tordoff J, Reith D. Changes in availability of paediatric medicines in Australia between 1998 and 2002. Br J Clin Pharmacol 2005;59(6):736-42.

Chui J, Tordoff J, Reith D. Changes in availability of paediatric medicines in Australia between 1998 and 2002. Br J Clin Pharmacol 2005;59(6):736-42.

Chui J, Tordoff J, Reith D. Changes in availability of paediatric medicines in Australia between 1998 and 2002. Br J Clin Pharmacol. 2005 Jun;59(6):736-42.

Clarke M. Doing new research? Don't forget the old - Nobody should do a trial without reviewing what is known. Chinese Journal of Evidence-Based Medicine 2005 5:6 (427-430)

Conroy S, McIntyre J. The use of unlicensed and off-label medicines in the neonate. Semin Fetal Neonatal Med 2005;10(2):115-22.

Cook SD. Clinical-trials registry. N J Med 2005;102(1-2):9.

Couzin J. Clinical trials. Facing criticism, industry offers to share data. Science. 2005;307(5707):189.

Grieve J, Tordoff J, Reith D, Norris P. Effect of the pediatric exclusivity provision on children's access to medicines. Br J Clin Pharmacol. 2005 Jun;59(6):730-5.

Helms PJ, Ekins Daukes S, Taylor MW, Simpson CR, McLay JS. Utility of routinely acquired primary care data for paediatric disease epidemiology and pharmacoepidemiology. Br J Clin Pharmacol 2005;59(6):684-90.

Hill P. Off licence and off label prescribing in children: litigation fears for physicians. Arch Dis Child 2005;90 Suppl 1:i17-8.

Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ 2005;330:956-8.

Mayor S. Drug companies agree to make clinical trial results public. BMJ 2005;330:109.

Moja PL, Moschetti I, D'Amico R. Outcome reporting bias in government-funded RCTs. CMAJ 2005;172(7):857; author reply 857.

Nunn T, Williams J. Formulation of medicines for children. Br J Clin Pharmacol. 2005 Jun;59(6):674-6.

Pandolfini C, Clavenna A, Bonati M. Studi clinici nei bambini. R&P 2005;21:29-30.

Saint-Raymond A, Brasseur D, Seigneuret N. [Medicines for children: time to act!]. Arch Pediatr. 2005 Aug;12(8):1195-8.

Sammons HM, Choonara I. Clinical trials of medication in children, 1996-2002. Eur J Clin Pharmacol. 2005 Apr;61(2):165-7. Epub 2005 Mar 11.

Standing JF, Khaki ZF, Wong IC. Poor formulation information in published pediatric drug trials. Pediatrics. 2005 Oct;116(4):e559-62.

Zarin DA, Tse T, Ide NC. Trial Registration at ClinicalTrials.gov between May and October 2005. N Engl J Med 2005;353(26):2779-87.

Abbasi K. Compulsory registration of clinical trials. BMJ 2004; 329(7467):637-8.

Caldwell PH, Murphy SB, Butow PN, Craig JC. Clinical trials in children. Lancet. 2004;364(9436):803-11.

Chalmers I. Government regulation is needed to prevent biased under-reporting of clinical trials. BMJ 2004;329:462.

Chan AW, Krleza-Jeric K, Schmid I, Altman DG. Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. CMAJ 2004;171(7):735-40.

Dove A. Shift in NIH focus fuels basic researchers' fears. Nat Med. 2004 Jun;10(6):555.

Drazen JM, Curfman GD. Public access to biomedical research. N Engl J Med. 2004;351(13):1343.

Dyer O. GlaxoSmithKline faces US lawsuit over concealment of trial results. BMJ 2004;328(7453):1395.

Filibeck U, Addis A, Tomino C, Martini N. European Clinical Trials Directive: the Italian position. Lancet 2004;363(9421):1651-2.

Filibeck U, Addis A, Tomino C, Martini N. European Clinical Trials Directive: the Italian position. Lancet. 2004 May 15;363(9421):1651-2.

Hartling L, Craig WR, Russell K, Stevens K, Klassen TP. Factors influencing the publication of randomized controlled trials in child health research. Arch Pediatr Adolesc Med. 2004 Oct;158(10):983-7.

Herxheimer A. Open access to industry's clinically relevant data. BMJ 2004;32964-5.

Herxheimer A. Open access to industry's clinically relevant data. BMJ. 2004 Jul 10;329(7457):64-5.

Jorgensen A, Bach KF, Friis K. Good Clinical Practice is now Obligatory in Academic Clinical Drug Research in the European Union. Pharmacol Toxicol 2004;94(2):57-8.

Jureidini JN, Doecke CJ, Mansfield PR, Haby MM, Menkes DB, Tonkin AL. Efficacy and safety of antidepressants for children and adolescents. BMJ 2004;328(7444):879-83.

No authors listed. The time is coming. Nat Rev Drug Discov. 2004 Nov;3(11):897-8.

Remuzzi G, Schieppati A, Boissel JP, Garattini S, Horton R. Independent clinical research in Europe. Lancet. 2004 Nov 6-12;364(9446):1723-6.

Sharma DC. Indian experts protest against off-label drug use. Lancet 2004 Apr 24;363(9418):1372.

Sharma DC. India pressed to relax rules on clinical trials. Drug companies claim changes are essential, but critics fear Indian patients will become guinea pigs. Lancet 2004 May 8;363(9420):1528-9.

Sharma DC. India pressed to relax rules on clinical trials. Drug companies claim changes are essential, but critics fear Indian patients will become guinea pigs. Lancet 2004;363(9420):1528-9.

The time is coming. [editorial] Nature Reviews 2004;3:897.

Turner EH. A taxpayer-funded clinical trials registry and results database. PLoS Med. 2004 Dec;1(3):e60.

Vermij P. Newly expanded European Union faces growing pains. Nat Med 2004 Jun;10(6):556.

Warlow C. Clinical research under the cosh again. BMJ 2004;329:241-2

WHO Press Release/23. WHO leads drive for international co-ordination of clinical research. 2 April 2004.

Woods K. Implementing the European clinical trials directive. BMJ. 2004 Jan 31;328(7434):240-1.

Zarocostas J. WHO boosts Internet access to clinical trials. Lancet. 2004 Apr 10;363(9416):1206.

Cuzzolin L, Zaccaron A, Fanos V. Unlicensed and off-label uses of drugs in paediatrics: a review of the literature. Fundam Clin Pharmacol 2003 Feb;17(1):125-31.

DM Matsui, ME Jardine, E Steer, V Cukernik, MJ Rieder. Where physicians look for information on drug prescribing for children. paediatr Child Health 2003;8:219-21.

Gorman RL. The march toward rational therapeutics in children. Pediatr Infect Dis J. 2003 Dec;22(12):1119-23.

Matsui D, Kwan C, Steer E, Rieder MJ. The trials and tribulations of doing drug research in children. CMAJ 2003 Nov 11;169(10):1033-4.

McKinney RE Jr. Congress, the FDA, and the fair development of new medications for children. Pediatrics. 2003 Sep;112(3 Pt 1):669-70.

Moberly T. A new clinical trials register. Clinical Researcher 2003;3(6):6-7.

Monika K. Krzyzanowska, MD, MPH; Melania Pintilie, MSc; Ian F. Tannock, MD, PhD Factors Associated With Failure to Publish Large Randomized Trials Presented at an Oncology Meeting. JAMA 2003;290:495-501.

Nunn AJ. Making medicines that children can take. Arch Dis Child. 2003 May;88(5):369-71.

Restivo J. Pediatric drug testing enters infancy. Nature Medicine 2003;9(6):631

Roberts R, Rodriguez W, Murphy D, Crescenzi T. Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. JAMA. 2003 Aug 20;290(7):905-11.

Salazar JC. Pediatric clinical trial experience: government, child, parent and physician's perspective. Pediatr Infect Dis J 2003 Dec;22(12):1124-7.

Schreiner MS. Paediatric clinical trials: redressing the imbalance. Nat Rev Drug Discov. 2003 Dec;2(12):949-61.

Tan E, Cranswick NE, Rayner CR, Chapman CB. Dosing information for paediatric patients: are they really "therapeutic orphans"? Med J Aust. 2003 Aug 18;179(4):195-8.

Trevathan E. Antiepileptic drug development for "therapeutic orphans". Epilepsia. 2003;44 Suppl 7:19-25.

Wong I, Sweis D, Cope J, Florence A. Paediatric Medicines Research in the UK. How to move forward? Drug Saf 2003;26(8):529-37.

't Jong GW, Stricker BH, Choonar I, van den Anker JN. Lack of effect of the European guidance on clinical investigation of medicines in children. Acta Paediatr. 2002;91(11):1233-8.

Conroy S. Unlicensed and off-label drug use: issues and recommendations. Paediatr Drugs. 2002;4(6):353-9.

Jull A, Chalmers I, Rodgers A. Clinical trials in NZ: does anybody know what's going on? N Z Med J. 2002 Dec 13;115(1167):U269.

Klassen TP, Wiebe N, Russell K, Stevens K, Hartling L, Craig WR, Moher D. Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias. Arch Pediatr Adolesc Med 2002;156(5):474-9.

Klassen TP, Wiebe N, Russell K, Stevens K, Hartling L, Craig WR, Moher D. Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias. Arch Pediatr Adolesc Med. 2002 May;156(5):474-9.

Manheimer E, Anderson D. Survey of public information about ongoing clinical trials funded by industry: evaluation of completeness and accessibility. BMJ. 2002 Sep 7;325(7363):528-31.

Steinbrook R. Testing medications in children. N Engl J Med. 2002 Oct 31;347(18):1462-70.

Thouvenel C, Geny MS, Demirdjian S, Vassal G. [Statutory pediatric informations available for anticancer drugs: inventory and proposals]. Arch Pediatr. 2002 Jul;9(7):685-93.

Tonks A. A clinical trials register for Europe BMJ 2002;325:1314.5

Tonks A. A clinical trials register for Europe. BMJ. 2002 Dec 7;325(7376):1314-5.

Turp JC, Schulte JM, Antes G. Nearly half of dental randomized controlled trials published in German are not included in Medline. Eur J Oral Sci 2002;110(6):405-11.

Bonati M, Impicciatore P, Pandolfini C. Medicines for children in Europe at the beginning of the new millennium. Paediatr Perinat Drug Ther 2001;4:82-4.

Dickson D. UK cancer charities concerned about new EU regulations. Nat Med. 2001 Dec;7(12):1264.

Hanley B, Truesdale A, King A, Elbourne D, Chalmers I. Involving consumers in designing, conducting, and interpreting randomised controlled trials: questionnaire survey. BMJ. 2001 Mar 3;322(7285):519-23.

Smyth RL. Research with children. Paediatric practice needs better evidence--gained in collaboration with parents and children. BMJ. 2001 Jun 9;322(7299):1377-8.

Stephenson T. Medicines for children--the last century and the next. Arch Dis Child. 2001 Sep;85(3):177-9.

Yaphe J, Edman R, Knishkowy B, Herman J. The association between funding by commercial interests and study outcome in randomized controlled drug trials. Fam Pract 2001;18(6):565-8

Autret E, Bonati M, Choonara I, Gorodischer R, Guignard JP, Hoppu K, et al. Medicines for children. Paediatr Perinat Drug Ther 2000;4:23.

Botstein P. Needs and new policies for medicines for children: the FDA, United States incentives, and international doings. Drug Inf J 2000;34:203-5.

Djulbegovic B, Lacevic M, Cantor A, Fields KK, Bennett CL, Adams JR, Kuderer NM, Lyman GH. The uncertainty principle and industry-sponsored research. Lancet. 2000 Aug 19;356(9230):635-8.

Impicciatore P., Pandolfini C., Bonati M. Database could give children safer medicines Nature 2000;405:882

Maurer SM, Firestone RB, Scriver CR. Science's neglected legacy. Nature. 2000 May 11;405(6783):117-20.

McCray AT. Better access to information about clinical trials. Ann Intern Med. 2000 Oct 17;133(8):609-14.

Riordan FA. Use of unlabelled and off licence drugs in children. Use of unlicensed drugs may be recommended in guidelines. BMJ. 2000 Apr 29;320(7243):1210.

Scroccaro G., Venturini F., Alberti C., Alberti MP., Caliumi F. Italian clinical trial registry is kept by pharmacists on local ethical committees BMJ 2000;320:1340

Cleophas RC, Cleophas TJ. Is selective reporting of clinical research unethical as well as unscientific? Int J Clin Pharmacol Ther 1999;37(1):1-7.

Goodare H, Lockwood S. Involving patients in clinical research. Improves the quality of research. BMJ. 1999 Sep 18;319(7212):724-5.

Impicciatore P, Choonara I. Status of new medicines approved by the European Medicines Evaluation Agency regarding paediatric use. Br J Clin Pharmacol. 1999 Jul;48(1):15-8.

Nahata MC. Lack of pediatric drug formulations. Pediatrics. 1999 Sep;104(3 Pt 2):607-9.

Wilson JT. An update on the therapeutic orphan. Pediatrics. 1999 Sep;104(3 Pt 2):585-90.

Wilton LV, Pearce G, Mann RD. The use of newly marketed drugs in children and adolescents prescribed in general practice. Pharmacoepidemiol Drug Saf. 1999 Apr;8 Suppl 1:S37-45.

Ceci A. Normativa e linee guida internazionali sulla sperimentazione clinica in ambito pediatrico. SIAR News 1997;20.

Niederhauser VP. Prescribing for children: issues in pediatric pharmacology. Nurse Pract. 1997 Mar;22(3):16-8, 23, 26-8 passim.

Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997;13;315(7109):640-5

Glantz LH. Conducting research with children: legal and ethical issues. J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1283-91.

Nahata MC. Inadequate pharmacotherapeutic data for drugs used in children: what can be done? Paediatr Drugs. 1999 Oct-Dec;1(4):245-9.

Walson PD, Getschman S, Koren G. Principles of drug prescribing in infants and children. A practical guide. Drugs. 1993 Aug;46(2):281-8.

Gilman JT, Gal P. Pharmacokinetic and pharmacodynamic data collection in children and neonates. A quiet frontier. Clin Pharmacokinet. 1992 Jul;23(1):1-9.

Hetherington J, Dickersin K, Chalmers I, Meinert CL. Retrospective and prospective identification of unpublished controlled trials: lessons from a survey of obstetricians and pediatricians. Pediatrics. 1989 Aug;84(2):374-80.

Rylance GW, Woods CG, Cullen RE, Rylance ME. Use of drugs by children. BMJ. 1988 Aug 13;297(6646):445-7.

Thompson DF, Heflin NR. Frequency and appropriateness of drug prescribing for unlabeled uses in pediatric patients. Am J Hosp Pharm. 1987 Apr;44(4):792-4.

Jonsen AR. Research involving children: Recommendations of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. Pediatrics. 1978 Aug;62(2):131-6.

Bosch X. European researchers up in arms over new clinical trials edict. Nat Med. 2003 Nov;9(11):1336.

Brion F, Nunn AJ, Rieutord A. Extemporaneous (magistral) preparation of oral medicines for children in European hospitals. Acta Paediatr. 2003 Apr;92(4):486-90.

Burns JP. Research in children. Crit Care Med. 2003 Mar;31(3 Suppl):S131-6.

Ceci A, Felisi M, Catapano M, Baiardi P, Cipollina L, Ravera S, Bagnulo S, Reggio S, Rondini G. Medicines for children licensed by the European Agency for the Evaluation of Medicinal Products. Eur J Clin Pharmacol. 2002 Nov;58(8):495-500. Epub 2002 Sep 25.

Chalmers I. Underreporting research is scientific misconduct. JAMA. 1990 Mar 9;263(10):1405-8.

Choonara I, Dunne J. Licensing of medicines. Arch Dis Child. 1998 May;78(5):402-3.

Christensen ML, Helms RA, Chesney RW. Is pediatric labeling really necessary? Pediatrics. 1999 Sep;104(3 Pt 2):593-7.

Chui J, Tordoff J, Kennedy J, Reith D. Trends in accessibility to medicines for children in New Zealand: 1998-2002. Br J Clin Pharmacol. 2004 Mar;57(3):322-7.

International Guidelines for etical review of Epidemiological Studies. Geneva, CIOMS. 1991

Medscape: Drug Trial Registry Called for in Wake of Antidepressant Findings: Known Suicide Risks Were Unpublicized

News-Medical.Net : A new online and searchable European register of clinical trials in children

No authors listed. How best to serve children. Lancet. 2000 Nov 11;356(9242):1619.

Policy Forum: The Need for a Centralized Clinical Trials Registry

Shirkey H. Therapeutic orphans. J Pediatr. 1968 Jan;72(1):119-20.

Trial Registration

Registration of clinical trials: a step forward but still a long path ahead. Haematologica 2006;91(3):295-6.

Satyanarayana K, Sharma A, Ganguly NK. Indian registry for clinical trials.Indian J Med Res. 2006;123(5):587-90.

Sim I, Chan AW, Gulmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Lancet 2006;367:1631-3.

Wille-Jorgensen P, Gluud C. Prospective registration of clinical trials. Colorectal Dis 2006;8(1):1.

Abbasi K, Godlee F. Next steps in trial registration. BMJ 2005;330(7502):1222-3.

Berlin JA. Why industry should register and disclose results of clinical studies--perspective of a recovering academic. BMJ 2005;330(7497):959.

Couzin J. Clinical trials. Facing criticism, industry offers to share data. Science 2005;307(5707):189.

De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB; International Committee of Medical Journal Editors. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. CMAJ 2005;172(13):1700-2.

Decullier E, Lheritier V, Chapuis F. Fate of biomedical research protocols and publication bias in France: retrospective cohort study. BMJ. 2005 Jul 2;331(7507):19. Epub 2005 Jun 20.

Drazen JM, Wood AJ. Trial registration report card. N Engl J Med. 2005 Dec 29;353(26):2809-11.

Drazen JM, Wood AJ. Trial registration report card. N Engl J Med 2005;353(26):2809-11.

European Federation of Pharmaceutical Industries and Associations. Joint position on the disclosure of clinical trial information via clinical trial registries and databases (January 2005)

Grass G. Clinical trial registration. N Engl J Med. 2005;352(2):198-9.

Gulmezoglu AM, Pang T, Horton R, Dickersin K. WHO facilitates international collaboration in setting standards for clinical trial registration. Lancet 2005;365:1829-31.

Gulmezoglu AM, Pang T, Horton R, Dickersin K. WHO facilitates international collaboration in setting standards for clinical trial registration. Lancet 2005;365(9474):1829-31.

Gulmezoglu AM, Pang T, Horton R, Dickersin K. WHO facilitates international collaboration in setting standards for clinical trial registration. Lancet. 2005 May 28-Jun 3;365(9474):1829-31.

Haug C, Gotzsche PC, Schroeder TV. Registries and registration of clinical trials. N Engl J Med. 2005;353(26):2811-2.

Haug C, Gotzsche PC, Schroeder TV. Registries and registration of clinical trials. N Engl J Med 2005;353(26):2811-2.

International Federation of Pharmaceutical Manufactures & Associations. IFMPMA improves biomedical data trasparency with launch of first worldwide clinical trials portal. Sept 21, 2005.

Kimball AB, Weinstock MA. Mandatory registration of clinical trials: a major step forward for evidence-based medicine. J Am Acad Dermatol 2005;52(5):890-2.

Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ 2005;330(7497):956-8.

No authors listed. Why should clinical trials be registered? CMAJ 2005;172(13):1653,1655.

Rivara FP. Registration of clinical trials. Arch Pediatr Adolesc Med 2005;159(7):685.

Rivara FP. Regostration of Clinical Trials. Arch Pediatr Adolesc Med 2005;159:685.

Wagena EJ, Knipschild P. The need for clinical trials registers: a case study in the field of addiction. Addiction 2005;100(10):1392-3.

Why should clinical trials be registered? CMAJ 2005;172(13):1653, 1655.

Zarin DA. Clinical trial registration. N Engl J Med 2005;352(15):1611.

Zarin DA. Clinical trial registration. N Engl J Med. 2005 Apr 14;352(15):1611.

Zielinski SL. Clinical trials registration efforts gain some ground. J Natl Cancer Inst 2005;97(6):410-1.

Antes G. Registering clinical trials is necessary for ethical, scientific and economic reasons. Bull World Health Organ. 2004 May;82(5):321.

Check E. WHO seeks system for tracking global clinical trials. 2004 Nov 11;432(7014):137.

D'Alonzo GE Jr. Clinical trial registration, a needed addition to the research process. J Am Osteopath Assoc. 2004 Oct;104(10):409-10.

De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB; International Committee of Medical Journal Editors. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med 2004;351(12):1250-1. Epub 2004 Sep 8.

Dyer O. GlaxoSmithKline faces US lawsuit over concealment of trial results. BMJ. 2004 Jun 12;328(7453):1395.

Dyer O. WHO to unveil global clinical trials register. Bull World Health Organ. 2004 Sep;82(9):714.

Eli §Lilly and Co. Lilly to disclose results of all clinical trials for marketed products via a publicly available registry [press release]. August 3, 2004. Available at: http://newsroom.lilly.com. Accessed August 3, 2004. Eli Lilly and Co. 2004.

Evans T, Gulmezoglu M, Pang T. Registering clinical trials: an essential role for WHO. Lancet 2004;363(9419):1413-4.

Furukawa TA. All clinical trials must be reported in detail and made publicly available. BMJ 2004;329(7466):626.

GlaxoSmithKline. GlaxoSmithKline announces major advance in on-line access to clinical trial information [press release]. June 18, 2004

Jones G, Abbasi K. Trial protocols at the BMJ. BMJ. 2004;329(7479):1360.

Rennie D. Trial Registration: A Great Idea Switches From Ignored to Irresistible. JAMA 2004;292(11):1359-62.

Rennie D. Trial registration: a great idea switches from ignored to irresistible. JAMA. 2004 Sep 15;292(11):1359-62. Epub 2004 Sep 8.

Spurgeon D. Medical journals fail to publish trials on major global diseases. BMJ 2004;328:1337

Spurgeon D. Canadian RCTs to have new registration rules. [News extra] BMJ 2004;329:252

Steinbrook R. Registration of clinical trials--voluntary or mandatory? N Engl J Med 2004;351(18):1820-2.

Steinbrook R. Public registration of clinical trials. N Engl J Med. 2004;351(4):315-7.

Dickersin K, Rennie D. Registering clinical trials. JAMA 2003;290(4):516-23.

Till JE, Phillips RA, Jadad AR. Finding Canadian cancer clinical trials on the Internet: an exploratory evaluation of online resources. CMAJ. 2003;168(9):1127-9.

Manheimer E, Anderson D. Survey of public information about ongoing clinical trials funded by industry: evaluation of completeness and accessibility. BMJ 2002;325(7363):528-31.

Horton R, Smith R. Time to register randomised trials. The case is now unanswerable. BMJ. 1999 Oct 2;319(7214):865-6.

Rennie D. Fair conduct and fair reporting of clinical trials. JAMA. 1999 Nov 10;282(18):1766-8.

Tonks A. Registering clinical trials. BMJ. 1999 Dec 11;319(7224):1565-8.

Dickersin K. How important is publication bias? A synthesis of available data. AIDS Educ Prev. 1997 Feb;9(1 Suppl):15-21.

Roberts I. Pharmaceutical industry is invited to respond to amnesty for unreported trials. BMJ. 1997 Sep 13;315(7109):683.

Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997;13;315(7109):640-5

Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ. 1997 Sep 13;315(7109):640-5.

Dickersin K, Garcia-Lopez F. Regulatory process effects clinical trial registration in Spain. Control Clin Trials. 1992 Dec;13(6):507-12.

Simes RJ. Publication bias: the case for an international registry of clinical trials. J Clin Oncol. 1986 Oct;4(10):1529-41.

Chan AW, Krleza-Jeric K, Schmid I, Altman DG. Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. CMAJ. 2004 Sep 28;171(7):735-40.

International Federation of Pharmaceutical Manufacturers & Associations. IFMPMA improves biomedical data trasparency with launch of first worldwide clinical trials portal [press release]. Sept 21, 2005

News

Tuffs A. German doctors press for a national trial register. BMJ 2005;331:178 (23 July), doi:10.1136/bmj.331.7510.178-d

AMA recommends that DHHS establish a registry for all U.S. Clinical Trials. For immediate release June 15, 2004

Bosch X. Europe's clinical trial database criticized. Nat Med 2004;10:555.

Choonara I. A New European Paediatric Clinical Trials Register. 2004; Autumn:12.

Dyer O. GlaxoSmithKline to set up comprehensive online clinical trials register. BMJ 2004;329:590 (11 September)

Elliott VS, AMNews staff. WHO plans global clinical trials registry. July 26, 2004.

Press release. Brussels, 29 September 2004. Commission proposes regulation aimed at promoting medicines for children.

Spurgeon D. Canadian RCTs to have new registration rules. BMJ 2004;329:252(31 July), doi:10.1136/bmj.329.7460.252-a.

Stagg Elliott V. WHO plans global clinical trials registry. The international organization hopes to build a comprehensive database in order to prevent the loss of unpublished results. American Medical News (amednews.com) July 26, 2004

World Health Organization. WHO leads drive for international coordination of clinical research. Press release WHO/23. Press release WHO/23, 2 April 2004

Fox DM, Bultena JP, McKelvie KE. President sings the pediatric research equity act of 2003 requiring specific assessment of safety and efficacy in children. FDA update 2003. Hogan & Hartson L.L.P.

Burgermeister J. New EU trials database is criticised for lack of openness. BMJ. 2004 May 8;328(7448):1094.